Brice APPENZELLER, PhD - Group Leader


Our primary research goals are the development of biomarkers for the identification of human exposure to different occupational and environmental pollutants such as pesticides, polycyclic aromatic hydrocarbons and persistent organic pollutants. Furthermore, we aim to expand the existing knowledge of the relationships between exposure to pollutants and subsequent biological/biochemical disorders.

Our analytical techniques are based on chromatography coupled with tandem mass spectrometry and we use blood, urine and hair samples as matrices. We namely developed methods to routinely assess alcohol consumption as well as the exposure to cigarette smoke in active and passive smoking

Strategic research goals

•Development of biomarkers assessing the exposure to pollutants

•Investigation of the adequacy of different biological matrices for the monitoring of exposure level

•Analyses of biological samples in national and international epidemiological studies

•Support to internal and external researchers for study design and results interpretation in biomarker identification

Head of research unit

Brice Appenzeller,PhD is the Group leader of HBRU. He also holds a position as Associate Professor at the University of Luxembourg. He is administrative board member of the Society of Hair Testing and expert in the work group on endocrine disruptors for the French Agency for Food, Environmental and Occupational Health & Safety.


• Population-based biomonitoring of exposure to persistent and non-persistent organic pollutants in the Grand Duchy of Luxembourg: Results from hair analysis.
August 01, 2021
2021 Aug. Environ Int.153:106526. Online ahead of print.
By: Peng FJ  Emond C  Hardy EM  Sauvageot N  Alkerwi A  Lair ML  Appenzeller BMR.

• Micronutrients and markers of oxidative stress and inflammation related to cardiometabolic health: results from the EHES-LUX study.
December 22, 2020
2020 Dec. Nutrients.13(1):5.
By: Ruiz-Castell M  Le Coroller G  Landrier JF  Kerkour D  Weber B  Fagherazzi G  Appenzeller BMR  Vaillant M  Bohn T.

• Is there an optimal sampling time and number of samples for assessing exposure to fast elimination endocrine disruptors with urinary biomarkers?
December 10, 2020
2020 Dec. Sci Total Environ.747:141185. Epub 2020 Jul 25.
By: Fays F  Palazzi P  Hardy EM  Schaeffer C  Phillipat C  Zeimet E  Vaillant M  Beausoleil C  Rousselle C  Slama R  Appenzeller BMR.

• Blood pharmacokinetic of 17 common pesticides in mixture following a single oral exposure in rats: implications for human biomonitoring and exposure assessment.
October 01, 2019
2019 Oct. Arch Toxicol.93(10):2849-2862. Epub 2019 Aug 19.
By: Chata C  Palazzi P  Grova N  Haan S  Emond C  Vaillant M  Appenzeller BMR.

• Challenges and benefits of integrating diverse sampling strategies in the observation of cardiovascular risk factors (ORISCAV-LUX 2) study.
February 04, 2019
2019 Feb. BMC Med Res Methodol.19(1):27.
By: Alkerwi A  Pastore J  Sauvageot N  Coroller GL  Bocquet V  d'Incau M  Aguayo G  Appenzeller B  Bejko D  Bohn T  Malisoux L  Couffignal S  Noppe S  Delagardelle C  Beissel J  Chioti A  Stranges S  Schmit JC.

• Exposure to polycyclic aromatic hydrocarbons in women living in the Chinese cities of BaoDing and Dalian revealed by hair analysis.
December 01, 2018
2018 Dec. Environ Int.121(Pt 2):1341-1354. Epub 2018 Nov 9.
By:Palazzi P  Mezzache S  Bourokba N  Hardy EM  Schritz A  Bastien P  Emond C  Li J  Soeur J  Appenzeller BMR.

• Hair analysis for the biomonitoring of pesticide exposure: comparison with blood and urine in a rat model.
August 01, 2017
2017 Aug. Arch Toxicol.91(8):2813-2825. Epub 2016 Dec 23.
By: Appenzeller BMR  Hardy EM  Grova N  Chata C  Fays F  Briand O  Schroeder H  Duca RC.



Brice Appenzeller - Group leader of the Human Biomonitoring Research Unit - Luxembourg Institute of Health

"The advantage of hair analysis is that it can cover a period of time ranging
from weeks to several months and therefore highlights chronic exposures
whilst a urine or blood analysis only corresponds to a few hours prior
to the taking of the sample,"
explained Brice Appenzeller, PhD,
Group Leader of the Human Biomonitoring Research Unit.

1A-B, rue Thomas Edison
1445 Strassen, LUXEMBOURG
Tel. : +352 26 970 421