POPEYE

Background

Although fetus is usually considered particularly vulnerable to toxics such as pesticides, assessing in utero exposure remains challenging.

Objectives

In the POPEYE project, hair samples were collected at delivery from a group of pregnant included in the ELFE (Etude Longitudinal Française depuis l’Enfance) cohort, and analysed for 140 pesticides and pesticide metabolites in order to assess exposure over pregnancy.

Results

The results demonstrated the multiple exposure of the mothers and showed association between exposure to pesticides and parameters (length, weight, head circumference) measured on the newborns. 

Relevant publications

Human exposure to PCBs, PBDEs and bisphenols revealed by hair analysis: A comparison between two adult female populations in China and France.
December 01, 2020
2020 Dec. Environ Pollut.267:115425. Epub 2020 Aug 15.
By: Peng FJ  Hardy EM  Beranger R  Mezzache S  Bourokba N  Bastien P  Li J  Zaros C  Chevrier C  Palazzi P  Soeur J  Appenzeller BMR.

Multiple pesticides in mothers' hair samples and children's measurements at birth: Results from the French national birth cohort (ELFE).
January 01, 2020
2020 Jan. Int J Hyg Environ Health.223(1):22-33. Epub 2019 Nov 8.
By: Beranger R  Hardy EM  Binter AC  Charles MA  Zaros C  Appenzeller BMR  Chevrier C.

Partners

• Inserm

• Santé publique France

• ANSES

Financial support

• Ecophyto (Ministère de l’Agriculture et de l’alimentation)

For more info

• Brice APPENZELLER - HBRU Group Leader